Effects of acute and chronic cilazapril treatment in spontaneously hypertensive rats.
نویسندگان
چکیده
منابع مشابه
Effects of cilazapril on the cerebral circulation in spontaneously hypertensive rats.
Chronic hypertension is associated with a lower cerebral vascular reserve due to thickening of the media of cerebral vessels. The goal of the present study was to determine if long-term inhibition of angiotensin converting enzyme with cilazapril, a new long-acting angiotensin converting enzyme inhibitor, could improve cerebral vascular reserve. For this purpose, two groups of 12 spontaneously h...
متن کاملEffect of Chronic Treatment of Spontaneously Hypertensive Rats
The effects of chronic treatment of spontaneously hypertensive rats (SHR) with methoxyverapamll (D 600) on blood pressure (BP) and on the In ritro contractile response of aortic and portal rein strips of rats were examined. D 600, prepared as the free base and dissolved in sesame oil, was injected subcutaneously daily into SHR to maintain the systolic blood pressure (SBP) at less than 130 ram H...
متن کاملEffects of cilazapril on cerebral vasodilatation in hypertensive rats.
Endothelium-dependent dilatation of cerebral arterioles is impaired during chronic hypertension. The goal of this study was to determine the effects of an angiotensin converting enzyme inhibitor, cilazapril, on endothelium-dependent dilatation in pial arterioles. Four-month-old Wistar-Kyoto (WKY) rats and stroke-prone spontaneously hypertensive rats (SHRSP) received cilazapril in their drinking...
متن کاملChronic nephrotoxic nephritis in spontaneously hypertensive rats.
(NTS) in Wistar rats (WR) and spontaneously hypertensive rats (SHR), our previous results suggested that sustained hypertension might aggravate the nephrotoxic processes or protract the course of glomerulonephritis. The present study was attemped to observe the more prolonged glomerular changes of nephrotoxic nephritis (NTN) until 15 weeks after the injection of NTS in SHR, compared with contro...
متن کاملChronic Treatment with Atrial Natriuretic Peptide in Spontaneously Hypertensive Rats: Beneficial Renal Effects and Sex Differences
OBJECTIVE The aim of this study was to investigate the effects of chronic treatment with atrial natriuretic peptide (ANP) on renal function, nitric oxide (NO) system, oxidative stress, collagen content and apoptosis in kidneys of spontaneously hypertensive rats (SHR), as well as sex-related differences in the response to the treatment. METHODS 10 week-old male and female SHR were infused with...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1989
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1989.tb03476.x